"Biology is the study of complicated things that give the appearance of having been designed for a purpose". Richard Dawkins
An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles.
Center for Biological Circuit Design - Caltech
The CBCD is developing new ways to design, build and analyze biological circuits. Biological circuits control information flow in biological systems, and as such are a core area of Information Science and Technology. The study of circuits cuts across vast areas of biology, from biochemistry, biophysics and genetics, to cell and developmental biology, to neurobiology and ecology. Understanding how to design and build circuits is crucial for the next generation of bioengineering. The study of biological circuits also opens up new areas for theory in computation. We combine the experimental biologist's desire to abstract the key principles from the richness and diversity of biological circuits, the physicist's sense of measurement and of simple underlying mechanisms, and the engineer's aesthetic of "to build is to understand," The CBCD is an interdisciplinary group of biologists and engineers from a broad range of engineering and biology disciplines.
Goals: We will deduce simple rules about biological circuits and understand how they act in circuits at the levels of molecules, cells, organisms and ecosystems. We will learn how to model, design, build and analyze biological circuits. We will forge effective interdisciplinary research teams and train interdisciplinary researchers, with fundamental connections between engineering and circuit biology, systems and molecular neuroscience.