Not usually on an individual scale, no. But when reproduction occurs then cellular division is occurring billions of times. There are going to be some errors
A cell itself cannot be a mutation. Mutations are errors in the genetic code of the cell, most of which are neutral or negative but sometimes can be positive.
If the mutation hinders the cell's ability to survive, that cell will die quickly and not produce many daughter cells, if any at all. If the mutation is neutral, it has no effect on the cell's survivability. If a mutation increases the cell's ability to survive and produce more cells, then it is positive.