and might a shift in antibody response be the piece at the center of the mosaic?
IgG4 acts as a form of “shepherd” for chronic exposure to things that should not always be pathogens. you get irritated by cat dander and your body responds with histamines and inflammation. but binding by something like like IgG4 would attenuate or even stop that response.
IgG4 is not about removing a pathogen, it’s about creating a “tolerance” by preventing your body from attacking whatever it has bound to. this may be fine for peanuts, but for a replicating respiratory pathogen with high organ affinity, it could be an all access arson pass to burn you down while you fail to elicit any effective immune response.
leaky (non-sterilizing) vaccines are exceedingly dangerous. there is a reason we don’t use them. viruses that can still replicate and spread get forced toward variants that take advantage of the vaccine and its having locked you into one, narrow response vector. and if they can find variants that elicit no IgG3 and lots of IgG4, they get to run riot.
and if you have created a widespread homogeneous herd immunity profile that can be taken advantage of, you’re really in for it.
everybody gets this and no one can generate sound immunity.
this would be entirely unprecedented in human history.