Are you actually going to defend any of those studies used?
I will do more than that, I will give you more.
1. So far as I can tell this was not a published study. I believe it may be part of a poster presentation for the first phase of
*this study* which ultimately found no such association and the lead author has specifically rebuked anti-vaccinators from using his data as evidence for their claims.
The study was retrospective looking at 400,000 patients and is simple math. OF course, you can deny math if you want. Here are two more studies for you, from pubmed:
The present study provides new epidemiological evidence of a significant relationship between increasing organic Hg exposure from Thimerosal-containing vaccines and the subsequent risk of PDD diagnosis in males and females.
CONCLUSIONS:
Routine childhood vaccination is an important public health tool to reduce the morbidity and mortality associated with infectious diseases, but the present study provides new epidemiological evidence supporting an association between increasing organic-Hg exposure from Thimerosal-containing childhood vaccines and the subsequent risk of an ASD diagnosis.
And once a study is made available, you don't get to decide who uses it. You might not like the attention it brings, as it affects your standing and reputation, but the results stand on their own.
2. Their key population of study was comparing a subgroup of only*31*boys with autism, 9 of which got the vaccine int he first month of life. The study also used children born from 1980 onward, even though the vaccine didn't become widely available until the 1990's so therefore there is the risk of changes in diagnosis and other exposures between these time periods would be a confounder (which the authors made no attempt to address).*
It was a published, and therefore, peer reveiewed study. You don't have to like the results, but they stand nonetheless.
3. Mouse study showing gender difference in sensitivity to thiomersal. Apart from being an animal study (therefore results should be extrapolated to humans with caution) the dosages used were no where near human exposures via vaccines.
Perhaps you are unaware of the process of medical discovery. Granted, mice studies have to be extended to humans before conclusions can be drawn, but that is the process.
Correlation precedes realization of likely causation which leads to the medical discovery of modality. This particular issue is stuck in a feedback loop of denial of correlation and the admission of causation, which is limiting the discovery of modality and is part of the reason autism occurrence is skyrocketing in this country. Denial of the preponderance of the evidence because it might affect one's research dollars is shameful medicine.
4. Essentially an animal study that suggests that genetic factors can be responsible for variations in mercury excretion rates. Again not readily extrapolatable to vaccines
Once again a step in the discovery of modality. Vaccines and/or their ingredients are reacting to cause neurological disorders and we need to discover the contributing factors.
5. Talks about the differences in expression of ASD symptoms based on genders (Highlighted was a statement re-iterating the widely known fact that autism is diagnosed in males more often than females). Does not talk about anything vaccine related.
You are correct.
6. An ecological study using population averages of autism rates compared with published vaccination schedules. Apart from such studies being extremely crude and impossible to attribute causality (there is no actual investigation linking individual exposures to measured end points, the chances for false positives with this method are FAR higher than those with individual breakdown of data) it is also relying on a lack of international variability in diagnosis, reporting and accuracy of reported prevalence rates. Furthermore the study is funded by anti-vaccinators, though this is not a major factor in dismissing this study.
Again, this is the medical process. Correlation always precedes admissions of causation. This is valid science.
7. Again an animal study, should be extrapolated to humans with caution. Interesting note: same authors and financial backers as the above study
.
You have it backwards. There is no money in being "anit-vax". These people put their careers on the line. MEdical professionals standing up the the pharmaceutical industry is bad for business. Trying to pretend that the money is in going against the main funding source for the medical professional, only makes you look desperate for ways to deny the obvious.
8. Not research/not a study. This is a review article and is merely the authors opinions and summary of how they view the current literature. Review articles are great for learning sometimes (I find them better than textbooks often) but should not be considered evidence for anything other than the authors opinions. Also again it is again by the some of the same people as above... (I'm seeing a pattern here...)
You clearly have no idea what a retrospective evidence based study is or how prevalent this type of study is in research science. This is again the search for correlation, which will lead to a closer look into verifying causation, which, when science finally admits the obvious, will lead to the search for modality. This particular study concludes that aluminum is likely a correlative factor in causation.
As this is step one in the research method, further study is required, but that doesn't mean you dismiss it because it doesn't clearly extrapolate modality. You need to brush up on the scientific method.
I may find correlation between those with tennis shoes and lower rates of heart disease, which could lead me to claim that owning tennis shoes causes heart health. But as a responsible scientist, I would instead look into what other factors attribute and upon closer examination would find that people with tennis show exercise more. That would lead to a finding that it is exercise that leads to heart health and science would then dig deeper into the mode of action that causes the body and heart to positively respond to exercise.
9. Again an environmental study looking at the increasing average population rates and then comparing against average population exposures. It suffers from the same limitations as any other study of its type, essentially I could use it as evidence for the cause of autism being anything which increased in frequency during the appropriate time period (perhaps children's exposure to The Simpsons? :chuckle: ) at best this study points to environmental exposures which might be worth further investigation, more so it points toward those exposures which are unlikely to be relevant and thus don't warrant further investigation (which makes the study of merit, so long as you don't try to over-extrapolate the data like you have). It is not even weak evidence of vaccines causing autism.
See above, and the scientific method.
10. A small study which shows an association between mercury and lead toxicity and autism, as well as a reduction of symptoms with chelation. First of all I don't think this data has been able to be replicated and thus is likely a false positive, furthermore the data is not suggestive of vaccines as these have not been shown to increase the levels of these metals in blood and hair by significant amounts to my knowledge. This study would more likely implicate chronic high environmental exposures (i.e. paints, water etc) if it were actually confirmed (which it hasn't)
It has been replicated:
Toxicological Status of Children with Autism vs. Neurotypical Children and the Association with Autism Severity
and here:
http://www.ncbi.nlm.nih.gov/pubmed/18006963
And I don't care what you think about "more likely implicate...." This is the scientific method. We find correlation, then dig down to find clear signs of causation then modality. This is science, you can blame it on whatever you want, but to exclude these exact heavy metals in vaccines, as a possible causative factor, because you like vaccines is not science, that is bias.
I think 10 studies is enough given the current poor quality of them.*I doubt you've actually checked the list let alone will actually defend it anyway, so I don't want to waste my time playing whack-a-mole with over 100 studies for no reason.
You have done nothing but prove you prefer your bias over science. Here are some more studies for you to find a reason to dismiss. Again, before you go off on a tangent, remember the scientific method. Some studies look for correlation, some causation and fewer still at this stage of discovery, modality:
1. Hepatitis B Vaccination of Male Neonates and Autism
Annals of Epidemiology, September 2009
CM Gallagher, MS Goodman, Stony Brook University Medical Center
Boys vaccinated as neonates had threefold greater odds for autism diagnosis compared to boys never vaccinated or vaccinated after the first month of life.
2. Porphyrinuria in childhood autistic disorder: Implications for environmental toxicity
Toxicology and Applied Pharmacology, 2006
Robert Natafa, et al, Laboratoire Philippe Auguste, Paris, France
These data implicate environmental toxicity in childhood autistic disorder.
3. Theoretical aspects of autism: Causes—A review
Journal of Immunotoxicology, January-March 2011
Helen V. Ratajczak, PhD
Autism could result from more than one cause, with different manifestations in different individuals that share common symptoms. Documented causes of autism include genetic mutations and/or deletions, viral infections, and encephalitis following vaccination.
4. Uncoupling of ATP-mediated Calcium Signaling and Dysregulated IL-6 Secretion in Dendritic Cells by Nanomolar Thimerosal
Environmental Health Perspectives, July 2006.
Samuel R. Goth, Ruth A. Chu Jeffrey P. Gregg
This study demonstrates that very low-levels of Thimerosal can contribute to immune system disregulation.
5. Gender-selective toxicity of thimerosal
Exp Toxicol Pathol. 2009 Mar;61(2):133-6. Epub 2008 Sep 3.
Branch DR, Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto
A recent report shows a correlation of the historical use of thimerosal in therapeutic immunizations with the subsequent development of autism; however, this association remains controversial. Autism occurs approximately four times more frequently in males compared to females; thus, studies of thimerosal toxicity should take into consideration gender-selective effects. The present study was originally undertaken to determine the maximum tolerated dose (MTD) of thimersosal in male and female CD1 mice. However, during the limited MTD studies, it became apparent that thimerosal has a differential MTD that depends on whether the mouse is male or female.
6. Comparison of Blood and Brain Mercury Levels in Infant monkeys exposed to Vaccines Containing Thimerosal
Environmental Health Perspectives, Aug 2005.
Thomas Burbacher, PhD, University of Washington
This study demonstrates clearly and unequivocally that ethyl mercury, the kind of mercury found in vaccines, not only ends up in the brain, but leaves double the amount of inorganic mercury as methyl mercury, the kind of mercury found in fish. This work is groundbreaking because little is known about ethyl mercury, and many health authorities have asserted that the mercury found in vaccines is the “safe kind.” This study also delivers a strong rebuke of the Institute of Medicine’s recommendation in 2004 to no longer pursue the mercury-autism connection.
7. Increases in the number of reactive glia in the visual cortex of Macaca fascicularis following subclinical long-term methyl mercury exposure
Toxicology and Applied Pharmacology, 1994
Charleston JS et al, Department of Pathology, School of Medicine, University of Washington
The identities of the reactive glial cells and the implications for the long-term function and survivability of the neurons due to changes in the glial population following subclinical long-term exposure to mercury are discussed.
8. Neuroglial Activation and Neuroinflammation in the Brain of Patients with Autism
Annals of Neurology, Feb 2005.
Diana L. Vargas, MD [Johns Hopkins University]
This study, performed independently and using a different methodology than Dr. Herbert (see above) reached the same conclusion: the brains of autistic children are suffering from inflammation.
9. Autism: A Brain Disorder, or a Disorder That Affects the Brain?
Clinical Neuropsychiatry, 2005
Martha R. Herbert M.D., Ph.D., Harvard University
Autism is defined behaviorally, as a syndrome of abnormalities involving language, social reciprocity and hyperfocus or reduced behavioral flexibility. It is clearly heterogeneous, and it can be accompanied by unusual talents as well as by impairments, but its underlying biological and genetic basis in unknown. Autism has been modeled as a brain-based, strongly genetic disorder, but emerging findings and hypotheses support a broader model of the condition as a genetically influenced and systemic.
10.
Activation of Methionine Synthase by Insulin-like Growth Factor-1 and Dopamine: a Target for Neurodevelopmental Toxins and Thimerosal
Molecular Psychiatry, July 2004.
Richard C. Deth, PhD [Northeastern University]
This study demonstrates how Thimerosal inhibits methylation, a central driver of cellular communication and development.
11. Validation of the Phenomenon of Autistic Regression Using Home Videotapes
Archives of General Psychiatry, 2005
Emily Werner, PhD; Geraldine Dawson, PhD, University of Washington
Conclusion This study validates the existence of early autistic regression.
12. Blood Levels of Mercury Are Related to Diagnosis of Autism: A Reanalysis of an Important Data Set
Journal of Child Neurology, 2007
M. Catherine DeSoto, PhD, Robert T. Hitlan, PhD -Department of Psychology, University of Northern Iowa
Excerpt: “We have reanalyzed the data set originally reported by Ip et al. in 2004 and have found that the original p value was in error and that a significant relation does exist between the blood levels of mercury and diagnosis of an autism spectrum disorder. Moreover, the hair sample analysis results offer some support for the idea that persons with autism may be less efficient and more variable at eliminating mercury from the bloo